Interleukin-7 receptor-α

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.^[5][6]

IL7R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DI2, 3DI3, 3UP1
Identifiers
Aliases	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDs	OMIM: 146661; MGI: 96562; HomoloGene: 1646; GeneCards: IL7R; OMA:IL7R - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 35,852,695 bp[1] End 35,879,603 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 4.16 cM Start 9,505,874 bp[2] End 9,530,262 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung granulocyte lymph node lower lobe of lung epithelium of nasopharynx appendix blood thymus upper lobe of left lung gallbladder Top expressed in blood mesenteric lymph nodes spleen thymus tibiofemoral joint subcutaneous adipose tissue bone marrow Paneth cell pharynx lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding interleukin-7 receptor activity protein binding cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane extracellular region external side of plasma membrane clathrin-coated vesicle membrane Biological process regulation of cell size regulation of DNA recombination positive regulation of T cell differentiation in thymus homeostasis of number of cells negative regulation of T cell mediated cytotoxicity cell surface receptor signaling pathway B cell proliferation T cell differentiation positive regulation of gene expression immune response cell morphogenesis lymph node development immunoglobulin production signal transduction interleukin-7-mediated signaling pathway positive regulation of cell population proliferation positive regulation of receptor signaling pathway via STAT membrane organization negative regulation of T cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3575 16197 Ensembl ENSG00000168685 ENSMUSG00000003882 UniProt P16871 P16872 RefSeq (mRNA) NM_002185 NM_008372 NM_001355680 RefSeq (protein) NP_002176 NP_032398 NP_001342609 Location (UCSC) Chr 5: 35.85 – 35.88 Mb Chr 15: 9.51 – 9.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.

References

1. GRCh38: Ensembl release 89: ENSG00000168685 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003882 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL7R interleukin 7 receptor".
6. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. S2CID 45181020.

Further reading

• Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848. S2CID 45365828.
• Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077.
• Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours". Histol. Histopathol. 18 (3): 911–23. PMID 12792903.
• Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841.
• Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13". Leukemia. 6 (7): 662–8. PMID 1378163.
• Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235. S2CID 8151834.
• Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter". Mol. Cell. Biol. 11 (6): 3052–9. doi:10.1128/MCB.11.6.3052. PMC 360143. PMID 2038316.
• Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7". J. Immunol. 153 (1): 97–109. doi:10.4049/jimmunol.153.1.97. PMID 7515933.
• van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain". Leukemia. 10 (8): 1317–25. PMID 8709637.
• Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice". Cell. 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624. S2CID 16192745.
• Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor". Nature. 391 (6670): 904–7. Bibcode:1998Natur.391..904C. doi:10.1038/36122. PMID 9495344. S2CID 205024726.
• Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216. S2CID 25873360.
• Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor". Immunity. 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656.
• Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271.
• Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency". Blood. 96 (8): 2803–7. doi:10.1182/blood.V96.8.2803. PMID 11023514.
• Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.

External links

• IL7R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P16871 (Human Interleukin-7 receptor subunit alpha) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P16872 (Mouse Interleukin-7 receptor subunit alpha) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.