Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor.[5] The interleukin 20 receptor, alpha subunit is also referred to as IL20R1[6] or IL20RA.[7] The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.[5]
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IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver.[7] IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.[8]