U.S. Route421 (also U.S. Highway 421, US421) is a diagonal northwest–southeast United States Numbered Highway in the states of NorthCarolina, Tennessee
U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to
U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with