Holy Cross Church, or variants thereof, may refer to:
- Holy Cross Church, Hattula, in Hattula, Finland, is the oldest church in the former Tavastia (Häme) province
- Holy Cross Church, Iisalmi, in Iisalmi, Finland
- Holy Cross Church, Tampere, the name given to a religious building affiliated with the Catholic Church and is located in the city of Tampere, Finland
- Church of the Holy Cross, Rauma, a medieval fieldstone church in Rauma, Finland. It is located in the UNESCO World Heritage Site of Old Rauma. The church stands by the small stream of Raumanjoki (Rauma river)
- Catholic Holy Cross Church, Augsburg
- Evangelical Holy Cross Church, Augsburg [de]
- Neuwerkskirche, Erfurt, dedicated to the Holy Cross
- Holy Cross Church, Frankfurt-Bornheim, a Roman Catholic church in the Bornheim district of Frankfurt am Main
- Kreuzkirche, Hanover
- Holy Cross Church, Lehre, currently a Lutheran church
- Holy Cross Church, Munich, the oldest preserved church in the city
- Holy Cross Church (Neuenwalde Convent), the church of the Neuenwalde Convent
- Abbey of the Holy Cross, Rostock, founded in the 13th century by Cistercian nuns
- Holy Cross Church, Braga, in Portuguese, Igreja de Santa Cruz is a Portuguese 17th century church in Braga, Portugal, dedicated to the Holy Cross
- Holy Cross Church, Banská Bystrica
England
- Holy Cross Church, Binstead, Isle of Wight
- Holy Cross Church, Bristol
- Holy Cross Church, Burley, Rutland
- Holy Cross Church, Bury, Cambridgeshire
- Church of the Holy Cross, Crediton, Devon
- Holy Cross Church, Leicester
- Holy Cross Church, Lincoln
- Church of the Holy Cross, Pershore, Worcestershire
- Holy Cross Church, St Pancras, London
- Holy Cross Church, Woodchurch, Wirral
- Holy Cross Church (Woodingdean), Woodingdean, Brighton and Hove
Massachusetts
- Holy Cross Church, Boston (former Holy Cross Cathedral), located on Franklin Street in Boston, Massachusetts. In 1808 the church became the Cathedral of the Holy Cross. It was designed by Charles Bulfinch and was the first church built for the city's Roman Catholics
- Cathedral of the Holy Cross (disambiguation)
- Elevation of Holy Cross Church, South Naknek, Alaska, listed on the NRHP in Bristol Bay Borough, Alaska
- Holy Cross Abbey (Cañon City, Colorado),
- Chapel of the Holy Cross (Holderness, New Hampshire)
- Holy Cross Monastery (West Park, New York)
- Holy Cross Monastery and Chapel, Cincinnati, Ohio
- St Cross Church (disambiguation)