that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. ERBB2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12)
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular
for HER2-positive breast cancer, have been developed based on the specific chromosomal abnormalities associated with these cancers. Chromosomal instability
DNA sequences on chromosomes. Fluorescence microscopy can be used to find out where the fluorescent probe is bound to the chromosomes. FISH is often used
associated with a polysomy 8 syndrome. Overexpression of the HER2/neu gene on chromosome 17 and some type of polysomy has been reported in 8-68% of breast