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From Wikipedia, the free encyclopedia
Grimm's Hydride Displacement Law is an early hypothesis, formulated in 1925, to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.
According to Grimm, each vertical column (of Table below) would represent a group of isosteres.
C | N | O | F | Ne | Na |
CH | NH | OH | FH | - | |
CH2 | NH2 | OH2 | FH2+ | ||
CH3 | NH3 | OH3+ | |||
CH4 | NH4+ |
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