Glutamate—tRNA(Gln) ligase

In enzymology, a glutamate—tRNA^Gln ligase (EC 6.1.1.24) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + tRNAGlx ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + glutamyl-tRNAGlx

Glutamate—tRNAGln ligase
Identifiers
EC no.	6.1.1.24
CAS no.	9068-76-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, L-glutamate, and tRNAGlx, whereas its 3 products are AMP, diphosphate, and glutamyl-tRNAGlx.

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlx ligase (AMP-forming). This enzyme is also called glutamyl-tRNA synthetase. This enzyme participates in glutamate metabolism.