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Glucagon-like peptide-1 receptor
Receptor activated by peptide hormone GLP-1 / From Wikipedia, the free encyclopedia
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The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6.[5][6] It is a member of the glucagon receptor family of GPCRs.[7] GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1,[8] and one transmembrane (TMD) domain[9] that binds the N-terminal region of GLP-1.[10][11][12] In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries[13] and extracellular surface are a trigger for biased agonism.[11]