Fibroblast activation protein, alpha
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Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene.[5]
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Prolyl endopeptidase FAP is a 170 kDa membrane-bound gelatinase. It was independently identified as a surface glycoprotein recognized by the F19 monoclonal antibody in activated fibroblasts[6] and a Surface Expressed Protease (seprase) in invasive melanoma cells.[7][8]