Insulin aspart
Rapid-acting man-made insulin / From Wikipedia, the free encyclopedia
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Insulin aspart, sold under the brand name NovoLog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes.[17] It is generally used by injection under the skin but may also be used by injection into a vein.[17] Maximum effect occurs after about 1–3 hours and lasts for 3–5 hours.[17] Generally a longer-acting insulin like insulin NPH is also needed.[17]
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Trade names | NovoLog, NovoRapid, Fiasp, others |
Biosimilars | Kirsty,[1] Trurapi,[2] Truvelog[3] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605013 |
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Routes of administration | Subcutaneous, intravenous |
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Formula | C256H381N65O79S6 |
Molar mass | 5825.60 g·mol−1 |
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Common side effects include low blood sugar, allergic reactions, itchiness, and pain at the site of injection.[17] Other serious side effects may include low blood potassium.[17] Use in pregnancy and breastfeeding is generally safe.[4] It works the same as human insulin by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver.[17] It is a manufactured form of human insulin; where a single amino acid has been changed, specifically a proline with an aspartic acid at the B28 position.[18]
Insulin aspart was approved for medical use in the United States in 2000.[17] In 2021, it was the 71st most commonly prescribed medication in the United States, with more than 9 million prescriptions.[19][20] Manufacturing involves yeast, which have had the gene for insulin aspart put into their genome.[21] This yeast then makes the insulin, which is harvested from the bioreactor.[22]