FCER1
From Wikipedia, the free encyclopedia
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE.[1] It consists of one alpha (FcεRIα – antibody binding site), one beta (FcεRIβ – which amplifies the downstream signal), and two gamma chains (FcεRIγ – the site where the downstream signal initiates) connected by two disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils[2] and is inducible in eosinophils.
Quick Facts High-affinity IgE receptor; alpha, Identifiers ...
High-affinity IgE receptor; alpha | |||||||
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Identifiers | |||||||
Symbol | FCER1A | ||||||
Alt. symbols | FcεRIα, FCE1A | ||||||
NCBI gene | 2205 | ||||||
HGNC | 3609 | ||||||
OMIM | 147140 | ||||||
RefSeq | NM_002001 | ||||||
UniProt | P12319 | ||||||
Other data | |||||||
Locus | Chr. 1 q23 | ||||||
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Quick Facts High affinity IgE receptor; beta, Identifiers ...
High affinity IgE receptor; beta | |||||||
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Identifiers | |||||||
Symbol | MS4A2 | ||||||
Alt. symbols | FcεRIβ, FCER1B, IGER, APY | ||||||
NCBI gene | 2206 | ||||||
HGNC | 7316 | ||||||
OMIM | 147138 | ||||||
RefSeq | NM_000139 | ||||||
UniProt | Q01362 | ||||||
Other data | |||||||
Locus | Chr. 1 q23 | ||||||
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Quick Facts High affinity IgE receptor; gamma, Identifiers ...
High affinity IgE receptor; gamma | |||||||
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Identifiers | |||||||
Symbol | FCER1G | ||||||
Alt. symbols | FcεRIγ | ||||||
NCBI gene | 2207 | ||||||
HGNC | 3611 | ||||||
OMIM | 147139 | ||||||
RefSeq | NM_004106 | ||||||
UniProt | P30273 | ||||||
Other data | |||||||
Locus | Chr. 1 q23 | ||||||
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