Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.[5][6]
Quick Facts Available structures, PDB ...
PTPN13 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Protein_PTPN13_PDB_1d5g.png/250px-Protein_PTPN13_PDB_1d5g.png) |
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Identifiers |
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Aliases | PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13 |
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External IDs | OMIM: 600267; MGI: 103293; HomoloGene: 7909; GeneCards: PTPN13; OMA:PTPN13 - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of paranasal sinus
- urethra
- human penis
- palpebral conjunctiva
- retinal pigment epithelium
- skin of arm
- renal medulla
- trigeminal ganglion
- gingival epithelium
- mucosa of pharynx
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| Top expressed in | - corneal stroma
- hair follicle
- mucosa of urinary bladder
- transitional epithelium of urinary bladder
- retinal pigment epithelium
- medullary collecting duct
- skin of external ear
- conjunctival fornix
- skin of back
- sciatic nerve
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BioGPS | |
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Wikidata |
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Close
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.[6]