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Disease which is constantly present in an area From Wikipedia, the free encyclopedia
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly present, or maintained at a baseline level, without extra infections being brought into the group as a result of travel or similar means.[1] The term describes the distribution of an infectious disease among a group of people or within a populated area.[2] An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (hyperendemic) or low (hypoendemic), and the disease can be severe or mild.[3][4] Also, a disease that is usually endemic can become epidemic.[3]
For example, chickenpox is endemic in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus Anopheles). Consequently, the number of people infected by malaria in the UK is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year to year, so chickenpox is considered endemic in the UK.
For an infection that relies on person-to-person transmission, to be endemic, each person who becomes infected with the disease must pass it on to one other person on average. Assuming a completely susceptible population, that means that the basic reproduction number (R0) of the infection must equal one. In a population with some immune individuals, the basic reproduction number multiplied by the proportion of susceptible individuals in the population (S) must be one. This takes account of the probability of each individual to whom the disease may be transmitted being susceptible to it, effectively discounting the immune sector of the population. So, for a disease to be in an endemic steady state or endemic equilibrium, it holds that
In this way, the infection neither dies out, nor does the number of infected people increase exponentially. An infection that starts as an epidemic will eventually either die out (with the possibility of it resurging in a theoretically predictable cyclical manner) or reach the endemic steady state, depending on a number of factors, including the virulence of the disease and its mode of transmission.[5]
If a disease is in an endemic steady state in a population, the relation above allows the basic reproduction number (R0) of a particular infection to be estimated. This in turn can be fed into a mathematical model for the epidemic. Based on the reproduction number, we can define the epidemic waves, such as the first wave, second wave, etc. for COVID-19 in different regions and countries.[6]
It has been claimed that endemic COVID-19 implies that the disease severity would be mild.[3] However, endemicity has no inherent relationship with disease severity. Endemic COVID-19 could be mild if previously acquired immunity reduces the risk of death and disability during future infections,[7] but in itself endemicity only means that there will be a steady, predictable number of sick people.[3][4]
This is a short, incomplete list of some infections that are usually considered endemic:
Smallpox was an endemic disease until it was eradicated through vaccination.[13]
The word endemic comes from the Greek: ἐν, en, "in, within" and δῆμος, demos, "people".[citation needed]
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