ESA most commonly refers to the European Space Agency.
ESA or Esa may also refer to:
- El Salvador, IOC country code
- Èze (French pronunciation: [ɛːz], Italian: Eza, Occitan: Esa), a commune in France
- École Sainte-Anne, a French public middle/high school in Fredericton, New Brunswick, Canada
- École supérieure des affaires (Beirut), a Lebanese business school
- École Supérieure des Affaires (Lille), a French business school
- Episcopal School of Acadiana, in Cade, Louisiana, United States
- Etobicoke School of the Arts, in Toronto, Ontario, Canada
- European Security Academy, in Wroclaw, Poland