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Estrogen-related receptor gamma
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.[5][6][7] It behaves as a constitutive activator of transcription.[8]
Quick Facts ESRRG, Available structures ...
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This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.[9] It also seems to be the target of bisphenol A (see below).