Estrogen-related receptor beta

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .^[5]

ESRRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LO1
Identifiers
Aliases	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2, Esrrb
External IDs	OMIM: 602167; MGI: 1346832; HomoloGene: 69108; GeneCards: ESRRB; OMA:ESRRB - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 76,310,712 bp[1] End 76,501,837 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D2|12 40.49 cM Start 86,407,891 bp[2] End 86,568,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle human kidney muscle of thigh apex of heart gastrocnemius muscle left ventricle renal medulla body of stomach right auricle skeletal muscle tissue Top expressed in neural layer of retina stria vascularis chorion retinal pigment epithelium vestibular sensory epithelium morula lumbar subsegment of spinal cord blastocyst secondary oocyte ooblast More reference expression data BioGPS n/a
Gene ontology Molecular function steroid binding nuclear receptor activity zinc ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding transcription factor binding metal ion binding steroid hormone receptor activity transcription coactivator activity protein binding RNA polymerase II complex binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component nucleus nucleoplasm condensed chromosome integrator complex chromosome cytoplasm Biological process regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic placenta development transcription, DNA-templated steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter intracellular receptor signaling pathway stem cell population maintenance negative regulation of transcription by RNA polymerase II cell population proliferation stem cell division cell dedifferentiation photoreceptor cell maintenance positive regulation of transcription, DNA-templated inner ear development positive regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of transcription involved in G2/M transition of mitotic cell cycle positive regulation of stem cell population maintenance regulation of stem cell division negative regulation of stem cell differentiation positive regulation of glycogen biosynthetic process positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2103 26380 Ensembl ENSG00000119715 ENSMUSG00000021255 UniProt O95718 Q61539 RefSeq (mRNA) NM_004452 NM_001379180 NM_001159500 NM_011934 RefSeq (protein) NP_004443 NP_001366109 NP_001152972 NP_036064 Location (UCSC) Chr 14: 76.31 – 76.5 Mb Chr 12: 86.41 – 86.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000119715 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021255 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ESRRB estrogen-related receptor beta".
6. Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I (November 2018). "Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation". The EMBO Journal. 37 (21): e95476. doi:10.15252/embj.201695476. PMC 6213284. PMID 30275266.

Further reading

• Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–94. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
• Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (October 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–326. doi:10.1006/geno.1997.4939. PMID 9344655.
• Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, et al. (December 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–4265. doi:10.1210/jcem.82.12.4470. PMID 9398750.
• Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, et al. (March 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–109. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
• Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (December 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–2162. doi:10.1210/mend.13.12.0381. PMID 10598588.
• Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (April 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–832. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265.
• Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (November 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–277. doi:10.1002/cne.10899. PMID 14528452. S2CID 86143014.
• Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (July 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–3486. doi:10.1210/en.2003-1682. PMID 15033914.
• Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (August 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–1254. doi:10.1096/fj.03-1088fje. PMID 15208259. S2CID 20159723.
• Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, et al. (August 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–275. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. S2CID 43765339.
• Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (February 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–1046. doi:10.1210/jc.2004-1211. PMID 15536156.
• Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, et al. (March 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–1844. doi:10.1210/jc.2004-1421. PMID 15598686.
• Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (February 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–579. doi:10.1210/jc.2004-1957. PMID 16332939.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.