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Estradiol benzoate/progesterone
Drug combination / From Wikipedia, the free encyclopedia
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Estradiol benzoate/progesterone (EB/P4), sold under the brand names Duogynon and Sistocyclin among others, is a combination medication of estradiol benzoate (EB), an estrogen, and progesterone (P4), a progestogen.[1][2][3] It has been formulated both as short-acting oil solutions and long-acting microcrystalline aqueous suspensions and is given by injection into muscle either once or continuously at regular intervals.[4][5]
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Combination of | |
---|---|
Estradiol benzoate | Estrogen |
Progesterone | Progestogen |
Clinical data | |
Trade names | Clinomin Forte, Duogynon, Lutrogen, Sistocyclin, Vermagest, others |
Other names | EB/P4 |
Routes of administration | Intramuscular injection (oil solution, aqueous suspension) |
ATC code | |
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EB/P4 was one of the first combined estrogen and progestogen medications to be introduced for medical use.[6] It was first marketed in Germany as an oil solution in 1950.[6] Microcrystalline EB/P4 in aqueous suspension was developed and marketed under the brand name Sistocyclin several years later.[6] EB/P4 was eventually superseded by longer-acting parenteral estrogen–progestogen combinations as well as by oral estrogen–progestogen combinations.[6]