Tetrahydrocannabinol
Psychoactive component of cannabis / From Wikipedia, the free encyclopedia
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"THC" redirects here. For other uses, see THC (disambiguation).
For the phytocannabinoid homologue of THC, that is much more potent than THC itself, see Tetrahydrocannabiphorol (THCP).
Tetrahydrocannabinol (THC) is a cannabinoid found in cannabis.[9] It is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers,[10] the term THC usually refers to the delta-9-THC isomer with chemical name (−)-trans-Δ9-tetrahydrocannabinol. It is a colorless oil.
Quick Facts Clinical data, Trade names ...
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Trade names | Marinol, Syndros |
Other names | (6aR,10aR)-delta-9-Tetrahydrocannabinol; (−)-trans-Δ9-Tetrahydrocannabinol; THC |
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Dependence liability | Physical: Low Psychological: Low–moderate |
Addiction liability | Relatively low: 9% |
Routes of administration | Oral, local/topical, transdermal, sublingual, inhaled |
Drug class | Cannabinoid |
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Bioavailability | 10–35% (inhalation), 6–20% (oral)[3] |
Protein binding | 97–99%[3][4][5] |
Metabolism | Mostly hepatic by CYP2C[3] |
Elimination half-life | 1.6–59 h,[3] 25–36 h (orally administered dronabinol) |
Excretion | 65–80% (feces), 20–35% (urine) as acid metabolites[3] |
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ECHA InfoCard | 100.153.676 |
Chemical and physical data | |
Formula | C21H30O2 |
Molar mass | 314.469 g·mol−1 |
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Specific rotation | −152° (ethanol) |
Boiling point | 155–157 °C (311–315 °F) 0.05mmHg,[6] 157–160°C @ 0.05mmHg[7] |
Solubility in water | 0.0028 mg/mL (23 °C)[8] |
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