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Cyclin E
Member of the cyclin family / From Wikipedia, the free encyclopedia
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Cyclin E is a member of the cyclin family.
Quick Facts Identifiers, Symbol ...
cyclin E1 | |||||||
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Identifiers | |||||||
Symbol | CCNE1 | ||||||
Alt. symbols | CCNE | ||||||
NCBI gene | 898 | ||||||
HGNC | 1589 | ||||||
OMIM | 123837 | ||||||
RefSeq | NM_001238 | ||||||
UniProt | P24864 | ||||||
Other data | |||||||
Locus | Chr. 19 q12 | ||||||
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Quick Facts Identifiers, Symbol ...
cyclin E2 | |||||||
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Identifiers | |||||||
Symbol | CCNE2 | ||||||
NCBI gene | 9134 | ||||||
HGNC | 1590 | ||||||
OMIM | 603775 | ||||||
RefSeq | NM_057749 | ||||||
UniProt | O96020 | ||||||
Other data | |||||||
Locus | Chr. 8 q22.1 | ||||||
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Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.
![Expression of cyclins through the cell cycle.](http://upload.wikimedia.org/wikipedia/commons/thumb/c/ce/Cyclin_Expression.svg/640px-Cyclin_Expression.svg.png)