Complement component 1q
Protein complex / From Wikipedia, the free encyclopedia
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The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 complex.
Quick Facts C1q domain, Identifiers ...
C1q domain | |||||||||
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Identifiers | |||||||||
Symbol | C1q | ||||||||
Pfam | PF00386 | ||||||||
Pfam clan | CL0100 | ||||||||
InterPro | IPR001073 | ||||||||
PROSITE | PDOC00857 | ||||||||
SCOP2 | 1c28 / SCOPe / SUPFAM | ||||||||
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Quick Facts Identifiers, Symbol ...
complement component 1, q subcomponent, A chain | |||||||
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Identifiers | |||||||
Symbol | C1QA | ||||||
NCBI gene | 712 | ||||||
HGNC | 1241 | ||||||
OMIM | 120550 | ||||||
RefSeq | NM_015991 | ||||||
UniProt | P02745 | ||||||
Other data | |||||||
Locus | Chr. 1 p36.3-34.1 | ||||||
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Quick Facts Identifiers, Symbol ...
complement component 1, q subcomponent, B chain | |||||||
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Identifiers | |||||||
Symbol | C1QB | ||||||
NCBI gene | 713 | ||||||
HGNC | 1242 | ||||||
OMIM | 120570 | ||||||
RefSeq | NM_000491 | ||||||
UniProt | P02746 | ||||||
Other data | |||||||
Locus | Chr. 1 p36.3-34.1 | ||||||
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Quick Facts Identifiers, Symbol ...
complement component 1, q subcomponent, C chain | |||||||
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Identifiers | |||||||
Symbol | C1QC | ||||||
Alt. symbols | C1QG | ||||||
NCBI gene | 714 | ||||||
HGNC | 1245 | ||||||
OMIM | 120575 | ||||||
RefSeq | NM_172369 | ||||||
UniProt | P02747 | ||||||
Other data | |||||||
Locus | Chr. 1 p36.11 | ||||||
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Antibodies of the adaptive immune system can bind antigen, forming an antigen-antibody complex. When C1q binds antigen-antibody complexes, the C1 complex becomes activated. Activation of the C1 complex initiates the classical complement pathway of the complement system. The antibodies IgM and all IgG subclasses except IgG4 are able to initiate the complement system.