Christophe is a male given name and a surname. It is a French variant of Christopher.
- Christophe Barratier, French filmmaker
- Christophe Beck, Canadian composer
- Christophe Dumaux, French opera singer
- Christophe Gans, French filmmaker
- Christophe Keckeis, chief of the Swiss Armed Forces
- Christophe Lemaitre, French sprinter
- Christophe Moreau, French cyclist
- Christophe Naegelen (born 1983), French politician
- Christophe Revault (1972–2021), French footballer
- Christophe Rinero, French cyclist
- Christophe Soulé, French mathematician
- Anne Christophe, French psychologist
- Didier Christophe (born 1956), French footballer, managing Pau FC
- Ernest Christophe (1827–1892), French sculptor
- Eugène Christophe (1885–1970), French cyclist
- Françoise Christophe (1923–2012), French actress
- François-Ferdinand Christophe (1794–1805), Haitian prince, son of Henri
- Fredler Christophe (born 2002), Haitian footballer
- Henri Christophe (1767–1820), Haitian Revolution leader, first King of Haiti
- Jean-François Christophe (born 1987), French footballer
- Joseph Christophe (1662–1748), French painter
- Marcel Christophe (born 1974), Luxembourgian footballer
- Paul Christophe (born 1971), French politician
- Pierre Christophe (1880–1971), French sculptor
- Robert Christophe (1938–2016), French Olympic swimmer