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Alteplase
Thrombolytic medication / From Wikipedia, the free encyclopedia
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Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter.[5] It is given by injection into a vein or artery.[5] Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells[6] and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.[7]
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Trade names | Activase, Actilyse, Cathflo Activase, others |
Other names | t-PA, rt-PA |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous |
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Formula | C2569H3928N746O781S40 |
Molar mass | 59042.52 g·mol−1 |
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It is on the World Health Organization's List of Essential Medicines.[8]
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