Caruso is an Italian surname derived from the Sicilian word for boy. In 19th century Sicily, the Carusi were young mine workers.
Notable people with the surname include:
- Anthony Caruso (actor) (1916–2003), an American character actor
- D.J. Caruso (born 1965), an American film director
- David Caruso (born 1956), American actor and producer
- Eugenia Caruso (born 1984), English actress and screenwriter
- Fred C. Caruso, American film producer
- Marcos Caruso (born 1952), Brazilian actor and author of soap operas
- Pino Caruso (1934–2019), Italian actor, author and TV personality
- Renai Caruso (born 1981), a Serbian actress living in Australia
- Robert Caruso, director of commercials, video, and film
- Sophia Anne Caruso (born 2001), American actress
- Anthony Caruso (entrepreneur), American business executive, president and CEO of CSA Group
- Dan Caruso (born 1963), American chairman and CEO of Zayo Group Holdings
- Gigi Caruso (born 2000), American businessperson and hearing loss advocate
- Henry Caruso (1922–2017), American businessman, founder of Dollar Rent A Car
- Rick Caruso (born 1959), American billionaire businessman in real estate
- Richard Caruso, American entrepreneur, founder and chairman of Integra Life Sciences
- Glenn Caruso (born 1974), American football coach and former player