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Canine Cushing's Syndrome
A common hormonal disease of the domestic dog / From Wikipedia, the free encyclopedia
Canine Cushing's syndrome - named after Harvey Cushing, who first described disease in humans - or canine hyperadrenocorticism (from ancient Greek ὑπέρ hyper, and Latin cortex adrenalis adrenal cortex) is a common hormonal disease of the domestic dog (Canis lupus familiaris). It is characterized by high blood levels of glucocorticoids, especially cortisol produced in the adrenal gland (hypercortisolism). The cause is usually tumors of the pituitary gland, which release an excess of the hormone ACTH, which controls the adrenal gland, and thus trigger an overproduction of cortisol. Cushing's syndrome occurs even more frequently due to the administration of synthetic glucocorticoids such as prednisolone or dexamethasone. These are frequently used in veterinary medicine to treat allergys, autoimmune diseases or inflammations and can trigger the same clinical picture with long-term use (iatrogenic Cushing's syndrome).
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Typical symptoms of the disease are increased drinking, increased urine output, increased appetite, pot belly, thin skin, muscle wasting and susceptibility to infections. Various laboratory tests can be used to confirm the diagnosis, but a definitive diagnosis is not always possible. To treat iatrogenic Cushing's syndrome, the synthetic glucocorticoid is gradually discontinued. In other forms of Cushing's disease, the drug Trilostane is usually used, which suppresses the formation of cortisol via enzyme inhibition. Surgical removal of the tumors causing the disease is also possible, but is performed much less frequently due to the frequent complications.