Ca2+/calmodulin-dependent protein kinase II
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Ca2+
/calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+
/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory.[1]
CaMKII is also necessary for Ca2+
homeostasis and reuptake in cardiomyocytes,[2]
chloride transport in epithelia,[3]
positive T-cell selection,[4]
and CD8 T-cell activation.[5]
Quick Facts Calcium/calmodulin dependent protein kinase II association domain, Identifiers ...
Calcium/calmodulin dependent protein kinase II association domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | CaMKII_AD | ||||||||
Pfam | PF08332 | ||||||||
Pfam clan | CL0051 | ||||||||
InterPro | IPR013543 | ||||||||
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Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.[6]