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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]
CLIC6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CLIC6, CLIC1L, chloride intracellular channel 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]
CLIC6 has been shown to interact with Dopamine receptor D3.[7]
CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]
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