Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation found on thrombocytes.[6]
Quick Facts ITGB3, Available structures ...
ITGB3 |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N |
|
|
Identifiers |
---|
Aliases | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2 |
---|
External IDs | OMIM: 173470; MGI: 96612; HomoloGene: 55444; GeneCards: ITGB3; OMA:ITGB3 - orthologs |
---|
|
|
|
|
|
Wikidata |
|
Close
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[8]
- Bray PF (October 1994). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thrombosis and Haemostasis. 72 (4): 492–502. PMID 7878622.
- Bennett JS (2001). "Platelet-fibrinogen interactions". Annals of the New York Academy of Sciences. 936 (1): 340–354. Bibcode:2001NYASA.936..340B. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. S2CID 25431334.
- Sajid M, Stouffer GA (February 2002). "The role of alpha(v)beta3 integrins in vascular healing". Thrombosis and Haemostasis. 87 (2): 187–193. doi:10.1055/s-0037-1612971. PMID 11858476.
- Quinn MJ, Byzova TV, Qin J, Topol EJ, Plow EF (June 2003). "Integrin alphaIIbbeta3 and its antagonism". Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (6): 945–952. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
- Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (January 2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
- Smith FB, Connor JM, Lee AJ, Cooke A, Lowe GD, Rumley A, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thrombosis Research. 112 (4): 209–216. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.
- Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Current Pharmaceutical Design. 10 (14): 1567–1576. doi:10.2174/1381612043384682. PMID 15134555.
- Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Current Medicinal Chemistry. 12 (1): 51–70. doi:10.2174/0929867053363522. PMID 15638730.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (August 2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". Journal of Thrombosis and Haemostasis. 3 (8): 1752–1762. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. S2CID 42666713.
- Bennett JS (December 2005). "Structure and function of the platelet integrin alphaIIbbeta3". The Journal of Clinical Investigation. 115 (12): 3363–3369. doi:10.1172/JCI26989. PMC 1297263. PMID 16322781.