NREP

Neuronal protein 3.1 is a protein that in humans is encoded by the NREP gene.^[5][6][7] It is highly expressed in the brain.^[8]

NREP
Identifiers
Aliases	NREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17, neuronal regeneration related protein
External IDs	OMIM: 607332; MGI: 99444; HomoloGene: 70874; GeneCards: NREP; OMA:NREP - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.1 Start 111,662,621 bp[1] End 111,997,464 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 33,570,072 bp[2] End 33,597,082 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum ganglionic eminence tibia ventricular zone right hemisphere of cerebellum pons Brodmann area 46 cartilage tissue frontal pole tendon of biceps brachii Top expressed in external carotid artery vestibular sensory epithelium cerebellar vermis Rostral migratory stream Gonadal ridge lobe of cerebellum fossa barrel cortex condyle internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process regulation of neuron differentiation axon regeneration regulation of transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9315 27528 Ensembl ENSG00000134986 ENSMUSG00000042834 UniProt Q16612 Q07475 RefSeq (mRNA) NM_001142474 NM_001142475 NM_001142476 NM_001142477 NM_001142478 NM_001142479 NM_001142480 NM_001142481 NM_001142482 NM_001142483 NM_004772 NM_001109988 NM_001109989 NM_001267717 NM_053078 RefSeq (protein) NP_001135946 NP_001135947 NP_001135948 NP_001135949 NP_001135950 NP_001135951 NP_001135952 NP_001135953 NP_001135954 NP_001135955 NP_004763 NP_001103458 NP_001103459 NP_001254646 NP_444308 Location (UCSC) Chr 5: 111.66 – 112 Mb Chr 18: 33.57 – 33.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000134986 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042834 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.
6. Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.
7. "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".
8. "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.

External links

• Human NREP genome location and NREP gene details page in the UCSC Genome Browser.

Further reading

• Taylor GA, Hudson E, Resau JH, Vande Woude GF (Feb 2000). "Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10.1074/jbc.275.6.4215. PMID 10660586.
• Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58. doi:10.1172/JCI15614. PMC 151607. PMID 12417574.
• McDonough WS, Tran NL, Berens ME (Sep 2005). "Regulation of glioma cell migration by serine-phosphorylated P311". Neoplasia. 7 (9): 862–72. doi:10.1593/neo.05190. PMC 1501936. PMID 16229809.
• Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH (Jul 2006). "Identification of P311 as a potential gene regulating alveolar generation". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 48–54. doi:10.1165/rcmb.2005-0475OC. PMC 2658697. PMID 16484684.