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Binswanger's disease
Medical condition / From Wikipedia, the free encyclopedia
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Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy,[1] is a form of small-vessel vascular dementia caused by damage to the white brain matter.[2] White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age.[3] This disease is characterized by loss of memory and intellectual function and by changes in mood. These changes encompass what are known as executive functions of the brain.[4] It usually presents between 54 and 66 years of age, and the first symptoms are usually mental deterioration or stroke.[5]
It was described by Otto Binswanger in 1894, and[6] Alois Alzheimer first used the phrase "Binswanger's disease" in 1902.[7] However, Jerzy Olszewski is credited with much of the modern-day investigation of this disease which began in 1962.[5][8]