Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), or Shoenfeld's syndrome, is a hypothesised autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011.[1] According to Shoenfeld, the syndrome is triggered by exposure to adjuvants and includes four conditions: "post-vaccination symptoms", macrophagic myofasciitis, Gulf war syndrome, sick building syndrome, and siliconosis.[2][3] Shoenfeld alleges that the syndrome is caused by adjuvants such as silicone, tetramethylpentadecane, pristane, and aluminum.[4] However, causality is difficult to prove because ASIA only occurs in a small fraction of patients exposed to these adjuvants.[5] Additionally, proponents of this theory allege that the disorder can manifest anywhere from 2 days to 23 years after exposure.[3] Shoenfeld has also named Sjögren's syndrome as potentially being another facet of ASIA.[6]
However, apart from the theoretical concept of ASIA, there is a lack of reproducible evidence for any causal relationship between adjuvant and autoimmune condition.[7] A study of 18,000 people showed that there is no merit to the theory of autoimmune/inflammatory syndrome induced by adjuvants.[8]
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