α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.[3][4]

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Cartoon depiction of the protein Streptococcus pyogenes family GH38 α-Mannosidase created using PyMol.[1][2]
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Isoenzymes

Humans express the following three α-mannosidase isoenzymes:

More information Identifiers, Symbol ...
mannosidase, α, class 2B, member 1
Identifiers
SymbolMAN2B1
Alt. symbolsMANB
NCBI gene4125
HGNC6826
OMIM609458
RefSeqNM_000528
UniProtO00754
Other data
EC number3.2.1.24
LocusChr. 19 cen-q13.1
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StructuresSwiss-model
DomainsInterPro
mannosidase, α, class 2B, member 2
Identifiers
SymbolMAN2B2
Alt. symbolsKIAA0935
NCBI gene23324
HGNC29623
RefSeqNM_015274
UniProtQ9Y2E5
Other data
EC number3.2.1.24
LocusChr. 4 p16.2
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StructuresSwiss-model
DomainsInterPro
mannosidase, α, class 2C, member 1
Identifiers
SymbolMAN2C1
Alt. symbolsMANA1, MANA
NCBI gene4123
HGNC6827
OMIM154580
RefSeqNM_006715
UniProtQ9NTJ4
Other data
EC number3.2.1.24
LocusChr. 15 q11-qter
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StructuresSwiss-model
DomainsInterPro
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Applications

It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]

Pathology

A deficiency can lead to α-mannosidosis.[6]

References

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