Paliperidone
Antipsychotic medication / From Wikipedia, the free encyclopedia
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Paliperidone, sold under the brand name Invega among others, is an atypical antipsychotic.[14] It is mainly used to treat schizophrenia and schizoaffective disorder.[14] It is marketed by Janssen Pharmaceuticals.[4]
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Trade names | Invega, Xeplion, Trevicta, others |
Other names | 9-hydroxyrisperidone; PP; PP1M; PP3M; PP6M; JNS-010; RO-92670; RO92670 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607005 |
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Routes of administration | By mouth, intramuscular |
Drug class | Atypical antipsychotic |
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Bioavailability | 28% (oral) |
Elimination half-life | 23 hours (by mouth) |
Excretion | 1% unchanged in urine 18% unchanged in feces |
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ECHA InfoCard | 100.117.604 |
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Formula | C23H27FN4O3 |
Molar mass | 426.492 g·mol−1 |
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The most frequent side effects include headache, insomnia (difficulty sleeping), sleepiness, parkinsonism (effects similar to Parkinson's disease such as shaking, muscle stiffness and slow movement), dystonia (involuntary muscle contractions), tremor (shaking), dizziness, akathisia (restlessness), agitation, anxiety, depression, increased weight, nausea, vomiting, constipation, dyspepsia (heartburn), diarrhea, dry mouth, tiredness, toothache, muscle and bone pain, back pain, asthenia (weakness), tachycardia (increased heart rate), high blood pressure, prolonged QT interval (an alteration of the electrical activity of the heart), upper respiratory tract infection (nose and throat infections) and cough.[8]
Paliperidone was approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia in December 2006,[4] and in the European Union in June 2007.[8] Paliperidone palmitate is a long-acting injectable formulation of paliperidone palmitoyl ester.[14][15] It is on the World Health Organization's List of Essential Medicines.[16] Paliperidone is available as a generic medication.[13]