4-hydroxybenzoate—CoA ligase

In enzymology, a 4-hydroxybenzoate—CoA ligase (EC 6.2.1.27) is an enzyme that catalyzes the chemical reaction

ATP + 4-hydroxybenzoate + CoA ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + 4-hydroxybenzoyl-CoA

4-Hydroxybenzoate—CoA ligase
Identifiers
EC no.	6.2.1.27
CAS no.	119699-80-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-hydroxybenzoate:CoA ligase (AMP-forming). Other names in common use include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA ligase. This enzyme participates in benzoate degradation via coa ligation.