4-Aminopyridine
Chemical compound / From Wikipedia, the free encyclopedia
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4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis,[7][8] and is indicated for symptomatic improvement of walking in adults with several variations of the disease.[9] It was undergoing Phase III clinical trials as of 2008[update],[10] and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010.[11] Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics[11][12] and as Fampyra in the European Union, Canada, and Australia. In Canada, the medication has been approved for use by Health Canada since February 10, 2012.[13]
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Names | |||
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Preferred IUPAC name
Pyridin-4-amine | |||
Other names | |||
Identifiers | |||
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3D model (JSmol) |
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ChEBI | |||
ChEMBL | |||
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DrugBank | |||
ECHA InfoCard | 100.007.262 | ||
EC Number |
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KEGG | |||
MeSH | 4-Aminopyridine | ||
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UNII | |||
CompTox Dashboard (EPA) |
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Properties | |||
C5H6N2 | |||
Molar mass | 94.1146 g/mol | ||
Appearance | colourless solid | ||
Melting point | 155 to 158 °C (311 to 316 °F; 428 to 431 K) | ||
Boiling point | 273 °C (523 °F; 546 K) | ||
polar organic solvents | |||
Basicity (pKb) | 4.83[1] | ||
Pharmacology | |||
N07XX07 (WHO) | |||
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Oral | |||
Pharmacokinetics: | |||
96% | |||
Legal status | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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