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3-Methoxytyramine
Chemical compound / From Wikipedia, the free encyclopedia
3-Methoxytyramine (3-MT), also known as 3-methoxy-4-hydroxyphenethylamine, is a human trace amine that occurs as a metabolite of the neurotransmitter dopamine.[1] It is formed by the introduction of a methyl group to dopamine by the enzyme catechol-O-methyl transferase (COMT). 3-MT can be further metabolized by the enzyme monoamine oxidase (MAO) to form homovanillic acid (HVA), which is then typically excreted in the urine.
Quick Facts Names, Identifiers ...
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Names | |
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Preferred IUPAC name
4-(2-Aminoethyl)-2-methoxyphenol | |
Other names
3-O-Methyldopamine | |
Identifiers | |
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ChEBI | |
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ECHA InfoCard | 100.122.789 ![]() |
MeSH | 3-methoxytyramine |
PubChem CID |
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CompTox Dashboard (EPA) |
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Properties | |
C9H13NO2 | |
Molar mass | 167.21 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Originally thought to be physiologically inactive, 3-MT has recently been shown to act as an agonist of human TAAR1.[1][2]