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Beta-lactamase
Class of enzymes / From Wikipedia, the free encyclopedia
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Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (β-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.
Serine beta-lactamase | |||||||||||
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![]() Structure of Streptomyces albus beta-lactamase | |||||||||||
Identifiers | |||||||||||
Symbol | β-lactamase domain | ||||||||||
Pfam | PF00144 | ||||||||||
Pfam clan | CL0013 | ||||||||||
InterPro | IPR001466 | ||||||||||
PROSITE | PS00146 | ||||||||||
SCOP2 | 56601 / SCOPe / SUPFAM | ||||||||||
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Metallo-beta-lactamase | |||||||||
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![]() Metallo-beta-lactamase L1 homotetramer, Stenotrophomonas | |||||||||
Identifiers | |||||||||
Symbol | ? | ||||||||
Pfam | PF00753 | ||||||||
Pfam clan | CL0381 | ||||||||
InterPro | IPR001279 | ||||||||
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β-lactamase | |||||||||
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![]() Action of β-lactamase and decarboxylation of the intermediate | |||||||||
Identifiers | |||||||||
EC no. | 3.5.2.6 | ||||||||
CAS no. | 9073-60-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Beta-lactamases produced by Gram-negative bacteria are usually secreted, especially when antibiotics are present in the environment.[1]