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β-Glucuronidase
Class of enzymes / From Wikipedia, the free encyclopedia
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β-Glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates.[2] Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate.[2][3][4] Human β-glucuronidase is located in the lysosome.[5] In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present in breast milk, which contributes to neonatal jaundice. The protein is encoded by the GUSB gene in humans[6][7] and by the uidA gene in bacteria.[8]
β-Glucuronidase | |||||||||
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Identifiers | |||||||||
EC no. | 3.2.1.31 | ||||||||
CAS no. | 9001-45-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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β-Glucuronidase | |||||||
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![]() β-Glucuronidase asymmetric unit showing active site residues Glu451, Tyr504, and Glu540, along with the potentially supporting Asn450 residue[1] | |||||||
Identifiers | |||||||
Symbol | GUSB | ||||||
NCBI gene | 2990 | ||||||
HGNC | 4696 | ||||||
OMIM | 611499 | ||||||
RefSeq | NM_000181 | ||||||
UniProt | P08236 | ||||||
Other data | |||||||
EC number | 3.2.1.31 | ||||||
Locus | Chr. 7 q11.21 | ||||||
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