La Flèche Wallonne 2010 var den 74. udgave af cykelløbet La Flèche Wallonne. Det blev arrangeret 21. april 2010.
25 hold blev inviteret til løbet, 17 af de 18 ProTour-hold og 8 professionelle kontinentalhold.
| ProTour-hold | Professionelle kontinentalhold |
|---|---|
| Rytter | Hold | Tid | |
|---|---|---|---|
| 1 |  Cadel Evans |
BMC Racing Team | 4:29.24 |
| 2 |  Joaquim Rodríguez |
Katusha | + 0.00 |
| 3 | Alberto Contador |
Astana | + 0.00 |
| 4 | Igor Antón |
Euskaltel-Euskadi | + 0.06 |
| 5 |  Damiano Cunego |
Lampre-Farnese Vini | + 0.09 |
| 6 |  Philippe Gilbert |
Omega Pharma-Lotto | + 0.11 |
| 7 |  Chris Horner |
Team RadioShack | + 0.11 |
| 8 | |
Caisse d'Epargne | + 0.11 |
| 9 |  Andy Schleck |
Team Saxo Bank | + 0.11 |
| 10 |  Ryder Hesjedal |
Garmin-Transitions | + 0.11 |
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