ZNF133

Protein 133 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF133.^[3][4][5]

ZNF133
Identifikatori
Aliasi	ZNF133
Vanjski ID-jevi	OMIM: 604075 HomoloGene: 48184 GeneCards: ZNF133
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek)[1] Bend 20p11.23 Početak 18,288,283 bp[1] Kraj 18,316,996 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7692	n/a
Ensembl	ENSG00000125846	n/a
UniProt	P52736 Q5JXW1	n/a
RefSeq (mRNK)	NM_001083330 NM_001282995 NM_001282996 NM_001282997 NM_001282998 NM_001282999 NM_001283000 NM_001283001 NM_001283002 NM_001283003 NM_001283004 NM_001283005 NM_001283006 NM_001283007 NM_001283008 NM_003434 NM_001352450 NM_001352451 NM_001352452 NM_001352453 NM_001352454 NM_001352455 NM_001352456 NM_001352457 NM_001352458 NM_001352459 NM_001352460 NM_001352461 NM_001352462 NM_001352463 NM_001352464	n/a
RefSeq (bjelančevina)	NP_001076799 NP_001269924 NP_001269925 NP_001269926 NP_001269927 NP_001269928 NP_001269929 NP_001269930 NP_001269931 NP_001269932 NP_001269933 NP_001269934 NP_001269935 NP_001269936 NP_001269937 NP_003425 NP_001339379 NP_001339380 NP_001339381 NP_001339382 NP_001339383 NP_001339384 NP_001339385 NP_001339386 NP_001339387 NP_001339388 NP_001339389 NP_001339390 NP_001339391 NP_001339392 NP_001339393	n/a
Lokacija (UCSC)	Chr 20: 18.29 – 18.32 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Opis

Smatra se da transkripcijski regulatorni proteini koji sadrže tandemno ponovljene domena cinkovih prstiju učestvuju u normalnoj i abnormalnoj ćelijskoj proliferaciji i diferencijaciji. Jedna bogataa klasa takvih transkripcijskih regulatora nalikuje proizvodu segmentacije Drosophila Kruppel, zbog prisustva ponovljenih Cys2-His2 (C2H2) domena cinkovih prstiju, koji su povezani konzerviranim sekvencama, zvanim H / C veze.

Skriningom biblioteke cDNK ljudskog insulina degeneriranim oligonukleotidom koji odgovara sekvenci H/C povezivača, Tommerup et al. (1993) izolirali su cDNK koje potencijalno kodiraju proteine cinkovih prstiju. Tommerup i Vissing (1995) izvršili su analizu sekvenci na nekoliko ovih cDNK i identificirali nekoliko novih gena proteina cinkovog prsta, uključujući ZNF133. Pronašli su dva oblika ZNF133 cDNK, koji predstavljaju različito prerađene transkripte; jedan predviđa protein cinkovog prsta tipa 654 od aminokiselina (PDB U09366) koji sadrži N-terminalni KRAB domen. Vissing et al. (1995) izvijestili su da izvedeni protein ZNF133 sadrži 13 domena cinkovog prsta kojima prethodi navodni degenerirani domen prstiju, te i KRAB A i B boks. Northern blot analizom otkrivena je ekspresija ZNF133 u svim ispitivanim tkivima.

Margolin et al, (1994) pokazali su da KRAB domen ZNF133 funkcionira kao snažan represivni domen transkripcije kada je stopljen sa domenom vezanja DNK kvasca GAL4.^[6][7][8][9]

Reference

1. GRCh38: Ensembl release 89: ENSG00000125846 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Tommerup N, Vissing H (Nov 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
4. Vissing H, Meyer WK, Aagaard L, Tommerup N, Thiesen HJ (Sep 1995). "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins". FEBS Lett. 369 (2–3): 153–7. doi:10.1016/0014-5793(95)00728-R. PMID 7649249.
5. "Entrez Gene: ZNF133 zinc finger protein 133".
6. Margolin, J. F., Friedman, J. R., Meyer, W. K., Vissing, H., Thiesen, H.-J., Rauscher, F. J., III. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Nat. Acad. Sci. 91: 4509-4513, 1994. [PubMed: 8183939]
7. Tommerup, N., Aagaard, L., Lund, C. L., Boel, E., Baxendale, S., Bates, G. P., Lehrach, H., Vissing, H. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. Hum. Molec. Genet. 2: 1571-1575, 1993. [PubMed: 8268908]
8. Tommerup, N., Vissing, H. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27: 259-264, 1995. [PubMed: 7557990]
9. Vissing, H., Meyer, W. K.-H., Aagaard, L., Tommerup, N., Thiesen, H.-J. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett. 369: 153-157, 1995. [PubMed: 7649249]

Dopunska literatura

• Lee SJ, Lee JR, Hahn HS, et al. (2007). "PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity". Exp. Mol. Med. 39 (4): 450–7. doi:10.1038/emm.2007.49. PMID 17934332.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ehringer MA, Thompson J, Conroy O, et al. (2004). "Human alcoholism studies of genes identified through mouse quantitative trait locus analysis". Addict Biol. 7 (4): 365–71. doi:10.1080/1355621021000005496. PMID 14578011.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Moosmann P, Georgiev O, Thiesen HJ, et al. (1998). "Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor". Biol. Chem. 378 (7): 669–77. doi:10.1515/bchm.1997.378.7.669. PMID 9278146.