CREB-regulirani transkripcijski koaktivator 2, znan i kao CRTC2, jest protein koji je kod ljudi kodiran genom CRTC2 sa hromosoma 1.[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 693 aminokiseline, a molekulska težina 73.302 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MATSGANGPG | | SATASASNPR | | KFSEKIALQK | | QRQAEETAAF | | EEVMMDIGST |
RLQAQKLRLA | | YTRSSHYGGS | | LPNVNQIGSG | | LAEFQSPLHS | | PLDSSRSTRH |
HGLVERVQRD | | PRRMVSPLRR | | YTRHIDSSPY | | SPAYLSPPPE | | SSWRRTMAWG |
NFPAEKGQLF | | RLPSALNRTS | | SDSALHTSVM | | NPSPQDTYPG | | PTPPSILPSR |
RGGILDGEMD | | PKVPAIEENL | | LDDKHLLKPW | | DAKKLSSSSS | | RPRSCEVPGI |
NIFPSPDQPA | | NVPVLPPAMN | | TGGSLPDLTN | | LHFPPPLPTP | | LDPEETAYPS |
LSGGNSTSNL | | THTMTHLGIS | | RGMGLGPGYD | | APGLHSPLSH | | PSLQSSLSNP |
NLQASLSSPQ | | PQLQGSHSHP | | SLPASSLARH | | VLPTTSLGHP | | SLSAPALSSS |
SSSSSTSSPV | | LGAPSYPAST | | PGASPHHRRV | | PLSPLSLLAG | | PADARRSQQQ |
LPKQFSPTMS | | PTLSSITQGV | | PLDTSKLSTD | | QRLPPYPYSS | | PSLVLPTQPH |
TPKSLQQPGL | | PSQSCSVQSS | | GGQPPGRQSH | | YGTPYPPGPS | | GHGQQSYHRP |
MSDFNLGNLE | | QFSMESPSAS | | LVLDPPGFSE | | GPGFLGGEGP | | MGGPQDPHTF |
NHQNLTHCSR | | HGSGPNIILT | | GDSSPGFSKE | | IAAALAGVPG | | FEVSAAGLEL |
GLGLEDELRM | | EPLGLEGLNM | | LSDPCALLPD | | PAVEESFRSD | | RLQ |
CRTC2, prvobitno zvani TORC2, je transkripcijski koaktivator za faktor transkripcije CREB i centralni regulator
glukoneogene ekspresije gena, kao odgovora na cAMP.[9] Smatra se da CRTC2 pokreće tumorigenezu kod LKB11/STK11-null karcinoma nemalih ćelija pluća (NSCLC).[10]
Pokazalo se da CRTC2 ima interakcije sa SNF1LK2[11] i YWHAQ.[11][12]
- Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (oktobar 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
- Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (august 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (august 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
- Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (oktobar 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
- Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (decembar 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
- Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (juli 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
- Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (septembar 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
- Yang Q, Inoki K, Ikenoue T, Guan KL (oktobar 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (juni 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC 1894761. PMID 17476304.
- Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (juni 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10175–80. Bibcode:2007PNAS..10410175K. doi:10.1073/pnas.0704170104. PMC 1891214. PMID 17548807.