Retinoblastomski protein (pRb, Rb, RB ili RB1) je tumor-supresorski protein čija nefunkcionalnost uzrokuje nekoliko glavnih kancera.[5] Jedna od funkcija pRb je sprečavanje prekomjerne proliferacije ćelija, inhibiranjem progresije ćelijskog ciklusa sve dok ćelija nije spremna za diobu. Kad je ćelija spremna za podjelu, pRb se fosforilira, deaktivirajući je, i dopušta se ćelijskom ciklusu da napreduje. Također je regruter nekoliko enzima za remodeliranje hromatina, kao što su metilaze i acetilaze.[6]
Kratke činjenice Dostupne strukture, PDB ...
RB1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/93/Protein_RB1_PDB_1ad6.png/250px-Protein_RB1_PDB_1ad6.png) |
Dostupne strukture |
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PDB | Pretraga ortologa: PDBe RCSB |
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Spisak PDB ID kodova |
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1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL, 4CRI |
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Identifikatori |
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Aliasi | RB1 |
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Vanjski ID-jevi | OMIM: 614041 MGI: 97874 HomoloGene: 272 GeneCards: RB1 |
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Ontologija gena |
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Molekularna funkcija | • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • transcription factor binding • phosphoprotein binding • kinase binding • GO:0001948, GO:0016582 protein binding • androgen receptor binding • identical protein binding • enzyme binding • ubiquitin protein ligase binding • importin-alpha family protein binding • disordered domain specific binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
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Ćelijska komponenta | • PML body • SWI/SNF complex • transcription regulator complex • Diobeno vreteno • cyclin/CDK positive transcription elongation factor complex • Hromatin • Jedro • Nukleoplazma • Rb-E2F complex
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Biološki proces | • negative regulation of cell population proliferation • negative regulation of mitotic cell cycle • neuron apoptotic process • androgen receptor signaling pathway • chromatin remodeling • negative regulation of smoothened signaling pathway • negative regulation of protein kinase activity • cell morphogenesis involved in neuron differentiation • mitotic cell cycle checkpoint signaling • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of macrophage differentiation • cellular response to xenobiotic stimulus • negative regulation of cell cycle • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • glial cell apoptotic process • regulation of cohesin loading • regulation of cell cycle • neuron maturation • Ćelijska dioba • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • positive regulation of mitotic metaphase/anaphase transition • GO:1903097, GO:1903098, GO:1903099 regulation of centromere complex assembly • enucleate erythrocyte differentiation • neuron differentiation • regulation of mitotic cell cycle • negative regulation of epithelial cell proliferation • skeletal muscle cell differentiation • sister chromatid biorientation • protein localization to chromosome, centromeric region • Ćelijski ciklus • striated muscle cell differentiation • Ras protein signal transduction • myoblast differentiation • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • neuron projection development • digestive tract development • maintenance of mitotic sister chromatid cohesion • regulation of lipid kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • hepatocyte apoptotic process • GO:0097285 Apoptoza • positive regulation of transcription regulatory region DNA binding • negative regulation of gene expression • regulation of cell growth • tissue homeostasis • GO:0009373 regulation of transcription, DNA-templated • G1/S transition of mitotic cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • aortic valve morphogenesis • negative regulation of inflammatory response • positive regulation of extracellular matrix organization • positive regulation of collagen fibril organization • negative regulation of myofibroblast differentiation • Ćelijska diferencijacija • negative regulation of cold-induced thermogenesis • negative regulation of protein serine/threonine kinase activity • negative regulation of tau-protein kinase activity • negative regulation of apoptotic signaling pathway
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 13: 48.3 – 48.6 Mb | Chr 14: 73.42 – 73.56 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
pRb pripada porodici džepnih proteina, čiji članovi imaju džep za funkcionalno vezivanje drugih proteina.[7][8] Ako se onkogeni proteini, poput onih koje proizvode ćelije inficirane visokorizičnim tipovima ljudskog papiloma virusa, veže i inaktivira pRb, to može dovesti do raka. Gen RB je možda bio odgovoran za evoluciju višećelijskih oblika u nekoliko loza života, uključujući životinje.[9]