Pretpostavljeni RNK-vezujući protein sličan Luc7 2 je protein koji je kod ljudi kodiran genom LUC7L2.[5][6]
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Zatvori
U nedavnoj (2021.) studiji navodi se da su ksidativna fosforilacija (OXPHOS) i glikoliza dva glavna puta za proizvodnju ATP-a. Oslanjanje na svako varira u zavisnosti od tkiva i stanja ćelija i može uticati na osjetljivost na bolesti. Još je nepoznat cijeli skup molekulskih mehanizama koji upravljaju relativnom ekspresijom i ravnotežom ova dva puta. Fokusirali su se na gene čiji gubitak dovodi do povećanja aktivnosti OXPHOS-a. Neočekivano, ova klasa gena je obogaćena za komponente mehanizama za preradu pre-iRNK, posebno za podjedinice U1 snRNP. Među njima, pokazano je da LUC7L2 potiskuje OXPHOS i podstiče glikolizu putem više mehanizama, uključujući (1) preradu glkoliznog enzima PFKM, radi suzbijanja sinteze glikogena, (2) prerada antiportera cistin/glutamat SLC7A11 (xCT) za suzbijanje oksidacije glutamata, i (3) sekundarna represija formiranja mitohondrijskog respiratornog superkompleksa. Dobijeni rezultati povezuju ekspresiju LUC7L2 i općenito, U1 snRNP s ćelijskim metabolizmom energije.[7]
Dužina polipeptidnog lanca je 392 aminokiseline, а molekulska težina 46.514 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MSAQAQMRAM | | LDQLMGTSRD | | GDTTRQRIKF | | SDDRVCKSHL | | LNCCPHDVLS |
GTRMDLGECL | | KVHDLALRAD | | YEIASKEQDF | | FFELDAMDHL | | QSFIADCDRR |
TEVAKKRLAE | | TQEEISAEVA | | AKAERVHELN | | EEIGKLLAKV | | EQLGAEGNVE |
ESQKVMDEVE | | KARAKKREAE | | EVYRNSMPAS | | SFQQQKLRVC | | EVCSAYLGLH |
DNDRRLADHF | | GGKLHLGFIE | | IREKLEELKR | | VVAEKQEKRN | | QERLKRREER |
EREEREKLRR | | SRSHSKNPKR | | SRSREHRRHR | | SRSMSRERKR | | RTRSKSREKR |
HRHRSRSSSR | | SRSRSHQRSR | | HSSRDRSRER | | SKRRSSKERF | | RDQDLASCDR |
DRSSRDRSPR | | DRDRKDKKRS | | YESANGRSED | | RRSSEEREAG | | EI |
Alexis A Jourdain, Bridget E Begg, Eran Mick, Hardik Shah, Sarah E Calvo, Owen S Skinner, Rohit Sharma , Steven M Blue, Gene W Yeo, Christopher B Burge, Vamsi K Mootha (2021): Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell, 81(9):1905-1919.e12; pmid: 33852893; pmcid: pmc8314041 (available on 2022-05-06); doi: 10.1016/j.molcel.2021.02.033
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