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Podjedinica 1 kompleksa integriranja je protein koji je kod ljudi kodiran genom INTS1.[5][6]
INTS1 | |||||||||||||||||||||||||
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Identifikatori | |||||||||||||||||||||||||
Aliasi | INTS1 | ||||||||||||||||||||||||
Vanjski ID-jevi | OMIM: 611345 MGI: 1915760 HomoloGene: 53111 GeneCards: INTS1 | ||||||||||||||||||||||||
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Ortolozi | |||||||||||||||||||||||||
Vrste | Čovjek | Miš | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNK) | |||||||||||||||||||||||||
RefSeq (bjelančevina) | |||||||||||||||||||||||||
Lokacija (UCSC) | Chr 7: 1.47 – 1.5 Mb | Chr 5: 139.74 – 139.76 Mb | |||||||||||||||||||||||
PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
Wikipodaci | |||||||||||||||||||||||||
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Dužina polipeptidnog lanca je 2.190 aminokiselina, а molekulska težina 244.297 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MNRAKPTTVR | RPSAAAKPSG | HPPPGDFIAL | GSKGQANESK | TASTLLKPAP | ||||
SGLPSERKRD | AAAALSSASA | LTGLTKRPKL | SSTPPLSALG | RLAEAAVAEK | ||||
RAISPSIKEP | SVVPIEVLPT | VLLDEIEAAE | LEGNDDRIEG | VLCGAVKQLK | ||||
VTRAKPDSTL | YLSLMYLAKI | KPNIFATEGV | IEALCSLLRR | DASINFKAKG | ||||
NSLVSVLACN | LLMAAYEEDE | NWPEIFVKVY | IEDSLGERIW | VDSPHCKTFV | ||||
DNIQTAFNTR | MPPRSVLLQG | EAGRVAGDLG | AGSSPHPSLT | EEEDSQTELL | ||||
IAEEKLSPEQ | EGQLMPRYEE | LAESVEEYVL | DMLRDQLNRR | QPIDNVSRNL | ||||
LRLLTSTCGY | KEVRLLAVQK | LEMWLQNPKL | TRPAQDLLMS | VCMNCNTHGS | ||||
EDMDVISHLI | KIRLKPKVLL | NHFMLCIREL | LSAHKDNLGT | TIKLVIFNEL | ||||
SSARNPNNMQ | VLYTALQHSS | ELAPKFLAMV | FQDLLTNKDD | YLRASRALLR | ||||
EIIKQTKHEI | NFQAFCLGLM | QERKEPQYLE | MEFKERFVVH | ITDVLAVSMM | ||||
LGITAQVKEA | GIAWDKGEKR | NLEVLRSFQN | QIAAIQRDAV | WWLHTVVPSI | ||||
SKLAPKDYVH | CLHKVLFTEQ | PETYYKWDNW | PPESDRNFFL | RLCSEVPILE | ||||
DTLMRILVIG | LSRELPLGPA | DAMELADHLV | KRAAAVQADD | VEVLKVGRTQ | ||||
LIDAVLNLCT | YHHPENIQLP | PGYQPPNLAI | STLYWKAWPL | LLVVAAFNPE | ||||
NIGLAAWEEY | PTLKMLMEMV | MTNNYSYPPC | TLTDEETRTE | MLNRELQTAQ | ||||
REKQEILAFE | GHLAAASTKQ | TITESSSLLL | SQLTSLDPQG | PPRRPPPHIL | ||||
DQVKSLNQSL | RLGHLLCRSR | NPDFLLHIIQ | RQASSQSMPW | LADLVQSSEG | ||||
SLDVLPVQCL | CEFLLHDAVD | DAASGEEDDE | GESKEQKAKK | RQRQQKQRQL | ||||
LGRLQDLLLG | PKADEQTTCE | VLDYFLRRLG | SSQVASRVLA | MKGLSLVLSE | ||||
GSLRDGEEKE | PPMEEDVGDT | DVLQGYQWLL | RDLPRLPLFD | SVRSTTALAL | ||||
QQAIHMETDP | QTISAYLIYL | SQHTPVEEQA | QHSDLALDVA | RLVVERSTIM | ||||
SHLFSKLSPS | AASDAVLSAL | LSIFSRYVRR | MRQSKEGEEV | YSWSESQDQV | ||||
FLRWSSGETA | TMHILVVHAM | VILLTLGPPR | ADDSEFQALL | DIWFPEEKPL | ||||
PTAFLVDTSE | EALLLPDWLK | LRMIRSEVLR | LVDAALQDLE | PQQLLLFVQS | ||||
FGIPVSSMSK | LLQFLDQAVA | HDPQTLEQNI | MDKNYMAHLV | EVQHERGASG | ||||
GQTFHSLLTA | SLPPRRDSTE | APKPKSSPEQ | PIGQGRIRVG | TQLRVLGPED | ||||
DLAGMFLQIF | PLSPDPRWQS | SSPRPVALAL | QQALGQELAR | VVQGSPEVPG | ||||
ITVRVLQALA | TLLSSPHGGA | LVMSMHRSHF | LACPLLRQLC | QYQRCVPQDT | ||||
GFSSLFLKVL | LQMLQWLDSP | GVEGGPLRAQ | LRMLASQASA | GRRLSDVRGG | ||||
LLRLAEALAF | RQDLEVVSST | VRAVIATLRS | GEQCSVEPDL | ISKVLQGLIE | ||||
VRSPHLEELL | TAFFSATADA | ASPFPACKPV | VVVSSLLLQE | EEPLAGGKPG | ||||
ADGGSLEAVR | LGPSSGLLVD | WLEMLDPEVV | SSCPDLQLRL | LFSRRKGKGQ | ||||
AQVPSFRPYL | LTLFTHQSSW | PTLHQCIRVL | LGKSREQRFD | PSASLDFLWA | ||||
CIHVPRIWQG | RDQRTPQKRR | EELVLRVQGP | ELISLVELIL | AEAETRSQDG | ||||
DTAACSLIQA | RLPLLLSCCC | GDDESVRKVT | EHLSGCIQQW | GDSVLGRRCR | ||||
DLLLQLYLQR | PELRVPVPEV | LLHSEGAASS | SVCKLDGLIH | RFITLLADTS | ||||
DSRALENRGA | DASMACRKLA | VAHPLLLLRH | LPMIAALLHG | RTHLNFQEFR | ||||
QQNHLSCFLH | VLGLLELLQP | HVFRSEHQGA | LWDCLLSFIR | LLLNYRKSSR | ||||
HLAAFINKFV | QFIHKYITYN | APAAISFLQK | HADPLHDLSF | DNSDLVMLKS | ||||
LLAGLSLPSR | DDRTDRGLDE | EGEEESSAGS | LPLVSVSLFT | PLTAAEMAPY | ||||
MKRLSRGQTV | EDLLEVLSDI | DEMSRRRPEI | LSFFSTNLQR | LMSSAEECCR | ||||
NLAFSLALRS | MQNSPSIAAA | FLPTFMYCLG | SQDFEVVQTA | LRNLPEYALL | ||||
CQEHAAVLLH | RAFLVGMYGQ | MDPSAQISEA | LRILHMEAVM |
INTS1 je podjedinica integratorskog kompleksa, koja se povezuje sa C-terminalnim domenom velike podjedinice RNK-polimeraze II (POLR2A; MIM 180660) i posreduje u 3' završnoj obradi malih jedarnih RNK U1 (RNU1; MIM 180680) i U2 (RNU2; MIM 180690) (Baillat et al., 2005 PubMed 16239144]).
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