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Factor VIII (medication)
Pharmaceutical drug / From Wikipedia, the free encyclopedia
Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII.[10][11] Certain preparations may also be used in those with von Willebrand's disease.[11] It is given by slow injection into a vein.[10]
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Trade names | Aafact, Kovaltry, others[1] |
Other names | octocog alfa |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous (IV) |
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Trade names | Adynovi |
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Trade names | Advate |
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Side effects include skin flushing, shortness of breath, fever, and red blood cell breakdown.[10][11] Allergic reactions including anaphylaxis may occur.[11] It is unclear if use during pregnancy is safe for the fetus.[12] A purified factor VIII concentrate is made from human blood plasma.[11] A recombinant version is also available.[10] People may develop antibodies to factor VIII such that this medication becomes less effective.[12]
Factor VIII was first identified in the 1940s and became available as a medication in the 1960s.[13][14] Recombinant factor VIII was first made in 1984 and approved for medical use in the United States in 1992.[15][16] It is on the World Health Organization's List of Essential Medicines.[17]