Nucleolus
Largest structure in the nucleus of eukaryotic cells / From Wikipedia, the free encyclopedia
For the solution concept in cooperative game theory, see Nucleolus (game theory).
The nucleolus (/njuːˈkliːələs, ˌnjuːkliˈoʊləs/; pl.: nucleoli /-laɪ/) is the largest structure in the nucleus of eukaryotic cells.[1] It is best known as the site of ribosome biogenesis, which is the synthesis of ribosomes. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to stress.[2] Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies"[3][4] and the nucleolus is being investigated as a target for cancer chemotherapy.[5][6]