![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/5/59/Histopathology_of_neurofibrillary_tangles_in_Alzheimer%2527s_disease_-_annotated.jpg/640px-Histopathology_of_neurofibrillary_tangles_in_Alzheimer%2527s_disease_-_annotated.jpg&w=640&q=50)
Neurofibrillary tangle
Aggregates of tau protein known as a biomarker of Alzheimer's disease / From Wikipedia, the free encyclopedia
Neurofibrillary tangles (NFTs) are intracellular aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies.
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/5/59/Histopathology_of_neurofibrillary_tangles_in_Alzheimer%27s_disease_-_annotated.jpg/320px-Histopathology_of_neurofibrillary_tangles_in_Alzheimer%27s_disease_-_annotated.jpg)