File:Considerations_for_the_design_of_engineered_live_bacterial_therapeutics.pdf
From Wikipedia, the free encyclopedia
Size of this JPG preview of this PDF file: 375 × 600 pixels. Other resolutions: 150 × 240 pixels | 300 × 480 pixels | 750 × 1,200 pixels.
Original file (750 × 1,200 pixels, file size: 394 KB, MIME type: application/pdf)
This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
DescriptionConsiderations for the design of engineered live bacterial therapeutics.pdf |
English: a Several aspects require consideration during the design of an engineered bacterial therapeutic. The selection of a chassis organism can be guided by the desired site of activity and pharmacokinetic properties of the chassis, as well as manufacturing feasibility. The design of genetic circuits may also be influenced by the circuit’s effectors, pragmatic concerns regarding inducer compounds, and the genetic stability of regulatory circuits. Critically, the design of an engineered bacterial drug may also be constrained by considerations for the needs of patients. b Optimal strain design often requires a balance between strain suitability for function in the target microenvironment and concerns for feasibility of manufacturing and clinical development.[1] |
Date | |
Source | https://doi.org/10.1038/s41467-020-15508-1 |
Author | Mark R. Charbonneau, Vincent M. Isabella, Ning Li & Caroline B. Kurtz |
Licensing
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Items portrayed in this file
depicts
8 April 2020
application/pdf
78cd57837d6817c3c2e096e17b0c5032757ae5d5
403,562 byte
1,200 pixel
750 pixel
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 17:45, 8 April 2020 | 750 × 1,200 (394 KB) | Rob Hurt | Uploaded a work by Mark R. Charbonneau, Vincent M. Isabella, Ning Li & Caroline B. Kurtz from https://doi.org/10.1038/s41467-020-15508-1 with UploadWizard |
File usage
The following pages on the English Wikipedia use this file (pages on other projects are not listed):
Global file usage
The following other wikis use this file:
- Usage on ar.wikipedia.org
- Usage on fa.wikipedia.org
- Usage on www.wikidata.org
Metadata
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
If the file has been modified from its original state, some details may not fully reflect the modified file.
Short title | Considerations for the design of engineered live bacterial therapeutics.pdf |
---|---|
Software used | Serif Affinity Designer (Mar 31 2020) |
Conversion program | PDFlib+PDI 9.1.2p1-i (OS X/macOS) |
Encrypted | no |
Page size | 360 x 576 pts |
Version of PDF format | 1.7 |