Anti–Saccharomyces cerevisiae antibody
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Anti-Saccharomyces cerevisiae antibodies (ASCAs) are antibodies against antigens presented by the cell wall of the yeast Saccharomyces cerevisiae. These antibodies are directed against oligomannose sequences α-1,3 Man (α-1,2 Man α-1,2 Man)n (n = 1 or 2).[1] ASCAs and perinuclear antineutrophil cytoplasmic antibodies (pANCAs) are the two most useful and often discriminating biomarkers for colitis.[2] ASCA tends to recognize Crohn's disease more frequently, whereas pANCA tend to recognize ulcerative colitis.[3]
Quick Facts Antigen isoform, Antigen source ...
Antigen isoform | Mannans |
---|---|
Antigen source | Saccharomyces cerevisiae |
Antigen gene | pro |
Affected organ(s) | Large Intestine |
Affected tissue(s) | Epithelium |
Associated disease(s) | Colitis |
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ASCA antibodies react to a yeast protein with mannans,[4] a 200-kDa glycoprotein.[5]