5-Methoxytryptamine
Chemical compound / From Wikipedia, the free encyclopedia
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.[1] It is biosynthesized via the deacetylation of melatonin in the pineal gland.[1]
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ECHA InfoCard | 100.009.231 |
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Formula | C11H14N2O |
Molar mass | 190.246 g·mol−1 |
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5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.[2][3][4][5][6][7][8] It has no affinity for the 5-HT3 receptor and its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors.[5][9] Its affinity for the 5-HT5A receptor is unknown.
Measured affinity for some receptors (incomplete list):
- 5-HT1B receptors (Ki = 35 nM) [10]
- 5-HT1D receptors (Ki = 7.3 nM)[11]
- 5-HT1E receptors (Ki = 3151 nM)[12]
- 5-HT1F receptors (Ki = 1166 nM)[13]
- 5-HT2A receptors (Ki = 295 nM)[14]
- 5-HT2B receptors (Ki = 16.4 nM)[15]
- 5-HT2C receptors (Ki = 52.48 nM) [16]
- 5-HT4 receptors (Ki = 501.18 nM)[17]
- 5-HT6 receptors (Ki = 69.18 nM)[18]
- 5-HT7 receptors (Ki = 5.01 nM)[19]