File:Basal_ganglia_in_treatment_of_Parkinson's.png
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Summary
DescriptionBasal ganglia in treatment of Parkinson's.png |
English: Circuits of the basal ganglia in treatment of Parkinson's disease. Levodopa, dopamine agonists and MAO-B inhibitors stimulate excitatory signals from the thalamus to the cortex by effects on the striatum, compensating for decreased dopaminergic signals from substantia nigra (seen at bottom right). Picture shows 2 coronal slices that have been superimposed to include the involved basal ganglia structures. + and - signs at the point of the arrows indicate respectively whether the pathway is excitatory or inhibitory in effect. Green arrows refer to excitatory glutamatergic pathways, red arrows refer to inhibitory GABAergic pathways and turquoise arrows refer to dopaminergic pathways that are excitatory on the direct pathway and inhibitory on the indirect pathway. Dis-inhibitory pathways are in effect excitatory on the feedback to the cortex, while dis-dis-inhibitory pathways are inhibitory. |
Date | |
Source | Derivative of File:Basal ganglia circuits.png |
Author | Mikael Häggström, based on image by Andrew Gillies/User:Anaru |
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Basal ganglia gallery
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Basal ganglia without Parkinson's disease.png.
(Derived from Basal ganglia circuits.svg with small change)
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Items portrayed in this file
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5 June 2010
image/png
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703,337 byte
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1,069 pixel
File history
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 07:35, 25 August 2010 | 1,069 × 1,486 (687 KB) | Mikael Häggström | Removed pars reticularis pathways for simplification, as they appear to be of relatively minor importance in Parkinson's disease. Reinserted brain at top. | |
16:43, 5 June 2010 | 1,062 × 1,047 (510 KB) | Mikael Häggström | {{Information |Description={{en|1=Circuits of the basal ganglia in treatment of Parkinson's disease. Levodopa, dopamine agonists and [[:en:Monoamine oxidase inhibitor|MAO-B inhibitors] |
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